Product Testing

Nautilus is recognized for OECD GLP compliance by the Standards Council of Canada (SCC). Under the Mutual Recognition Arrangement (MRA) between laboratory accreditation organizations, each organization recognizes the equivalence of the accreditation performed by its overseas counterparts and promotes the equivalence of such accreditation within its own economy. Our GLP recognized facility provides comprehensive testing services in support of international product registration for a range of regulatory programs including REACH, New Substances Notification (NSN), High Production Volume (HPV) programs. Through associated laboratories, we provide mammalian testing and specialized analytical chemistry.

  • Nautilus provides product testing services to characterise the potential impacts of chemical products on the environment.
  • Aquatic toxicity testing may be helpful to chemical manufacturers that wish to evaluate their products for environmental hazard assessments. 
  • Ready biodegradability tests (RBT) can be used to determine if products are persistent in the environment or biodegradable by micro-organisms in municipal wastewater or seawater. 
  • The information obtained from these tests may also be used for Material Safety Data Sheets, MSDS, or to provide information necessary for regulatory authorities. 
  • Additionally, product testing results may be used to substantiate claims that a product is environmentally friendly or to obtain Ecologo or other Green Label certifications. 
  • Nautilus can also evaluate the potential hazard of materials to marine or estuarine species for Transportation of Dangerous Goods (TDG) guidelines, OSPAR, or other environmental regulations.
  • Nautilus offers the following testing methods used to characterize the toxicity and biodegradability of products:
    • Acute Tests:
      • OECD 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test, 2011
      • OECD 202: Daphnia sp. Acute Immobilisation Test, 2004
      • OECD 203: Fish, Acute Toxicity Test, 1992
      • Microtox Test
    • Sublethal Tests: 
      • OECD 210: Fish, Early Life Stage Toxicity Test
      • OECD 211: Daphnia magna Reproduction Test
      • OECD 221: Lemna sp. Growth Inhibtion
    • Biodegradability: 
      • OECD 301D: Closed Bottle Test
      • OECD 301F: Manometric Respirometry Test
      • OECD 306: Biodegradability in Seawater
  • Nautilus is an OECD 17025 accredited laboratory and is inspected biannually by the Canadian Association for Laboratory Accreditation

Related Selected Publications and Presentations

  • Eickhoff C. 2014. Testing difficult substances: strategies for poorly water soluable test items. Integrated Environmental Assessment and Management. 10:476-477
  • Hughes S, Just P, Nguyen T, Eickhoff C. 2012. Assessing the aquatic toxicity of amine and nitrosamine compounds in carbon capture systems. 39th Aquatic Toxicity Workshop, September 30 – October 2, 2012, Sun Peaks, BC.
  • Johanning K, Hancock G, Escher B, Adekola A, Bernhard M, Cowan-Ellsberry C, Domoradzki J, Dyer S, Eickhoff C, Embry M, Erhardt S, Fitzsimmons P, Halder M, Hill J, Holden D, Johnson R, Rutishauser S, Segner H, Schultz I, Nichols J. 2012. Assessment of metabolic stability using rainbow trout (Oncorhynchus mykiss) liver S9 fraction. Current Protocols in Toxicology. Supplement 53: Unit 14.10: 1-28
  • Eickhoff C, Mitchell G, Leggett M, O’Grodnick J, Arnot K. 2010. Measuring bioconcentration and biomagnification potential of bifenthrin in Daphna magna. SETAC North America 31st Annual Meeting, November 7-11, 2010, Portland, OR.
  • Eickhoff C, Mitchell G, Leggett M, O’Grodnick J, Arnot K. 2010. Measuring bioconcentration and biomagnification potential of bifenthrin in Bluegill Sunfish, Lepomis macrochirus. SETAC North America 31st Annual Meeting, November 7-11, 2010, Portland, OR.
  • Arnot J, Armitage J, Mitchell G, Leggett M, O’Grodnick J, Eickhoff C, Hardy I. 2010. Integrating laboratory and field data with mass balance models for bioaccumulation and exposure assessment: A case study with bifenthrin. SETAC North America 31st Annual Meeting, November 7-11, 2010, Portland, OR.
  • Embry M, Adekola A, Bernhard M, Cowan- Ellsberry C, DyerS, Eickhoff C, Erhardt S, Halder M, Hancock G, Johanning K, Nichols J, Sharpe A. 2010. Validation of the in vitro Rainbow Trout (Oncorhynchus mykiss) liver S9 metabolic assay to assess bioaccumulation potential of chemicals.  SETAC North America 31st Annual Meeting, November 7-11, 2010, Portland, OR.
  • Curran C, Grassley J, Grue C. 2004. Toxicity of R-11® surfactant to juvenile rainbow trout: Does size matter? Bulletin of Environmental Contamination and Toxicology. 72: 401-408.
  • ​Smith B, Curran C, Brown K, Cabarrus J, Gown J, McIntrye J, Moreland E, Wong V, Grassley J,  Grue C. 2004. Toxicity of four surfactants to juvenile rainbow trout: Implications for over-water use. Bulletin of Environmental Contamination and Toxicology. 72: 647-654.

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